Package: DRviaSPCN
Type: Package
Title: Drug Repurposing in Cancer via a Subpathway Crosstalk Network
Version: 0.1.5
Maintainer: Junwei Han <hanjunwei1981@163.com>
Authors@R: c(person(given = "Junwei", family = "Han", email = "hanjunwei1981@163.com", role  = c("aut", "cre", "cph")),
             person(given = "Jiashuo", family = "Wu", role  = "aut"))
Description: A systematic biology tool was developed to repurpose drugs
        via a subpathway crosstalk network. The operation modes include
        1) calculating centrality scores of SPs in the context of gene
        expression data to reflect the influence of SP crosstalk, 2)
        evaluating drug-disease reverse association based on disease-
        and drug-induced SPs weighted by the SP crosstalk, 3)
        identifying cancer candidate drugs through perturbation
        analysis. There are also several functions used to visualize
        the results.
License: GPL (>= 2)
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.3.2
Imports: GSVA, clusterProfiler, graphics, igraph, pheatmap, stats
Depends: R (>= 3.6)
Suggests: rmarkdown, knitr, DT
VignetteBuilder: knitr
NeedsCompilation: no
Packaged: 2026-06-09 06:59:25 UTC; root
Author: Junwei Han [aut, cre, cph], Jiashuo Wu [aut]
Config/pak/sysreqs: libcairo2-dev cmake libfontconfig1-dev
        libfreetype6-dev libglpk-dev make libmagick++-dev gsfonts
        libicu-dev libpng-dev libuv1-dev libxml2-dev libssl-dev
        zlib1g-dev
Repository: https://hanjunwei-lab.r-universe.dev
Date/Publication: 2025-01-09 11:20:06 UTC
RemoteUrl: https://github.com/cran/DRviaSPCN
RemoteRef: HEAD
RemoteSha: e98d94437a388865ba9c39f6f2fa4d38b4c95d02