{ "_id": "6aabd8983d719c1f8406fecc", "Package": "DRviaSPCN", "Type": "Package", "Title": "Drug Repurposing in Cancer via a Subpathway Crosstalk Network", "Version": "0.1.5", "Maintainer": "Junwei Han ", "Authors@R": "c(person(given = \"Junwei\", family = \"Han\", email = \"hanjunwei1981@163.com\", role = c(\"aut\", \"cre\", \"cph\")),\nperson(given = \"Jiashuo\", family = \"Wu\", role = \"aut\"))", "Description": "A systematic biology tool was developed to repurpose drugs\nvia a subpathway crosstalk network. The operation modes include\n1) calculating centrality scores of SPs in the context of gene\nexpression data to reflect the influence of SP crosstalk, 2)\nevaluating drug-disease reverse association based on disease-\nand drug-induced SPs weighted by the SP crosstalk, 3)\nidentifying cancer candidate drugs through perturbation\nanalysis. There are also several functions used to visualize\nthe results.", "License": "GPL (>= 2)", "Encoding": "UTF-8", "LazyData": "true", "RoxygenNote": "7.3.2", "VignetteBuilder": "knitr", "NeedsCompilation": "no", "Packaged": { "Date": "2026-09-17 11:44:26 UTC", "User": "root" }, "Author": "Junwei Han [aut, cre, cph], Jiashuo Wu [aut]", "Config/pak/sysreqs": "libcairo2-dev cmake libfontconfig1-dev\nlibfreetype6-dev libglpk-dev make libmagick++-dev gsfonts\nlibicu-dev libpng-dev libuv1-dev libxml2-dev libssl-dev\nzlib1g-dev", "Repository": "https://hanjunwei-lab.r-universe.dev", "Date/Publication": "2025-01-09 11:20:06 UTC", "RemoteUrl": "https://github.com/cran/DRviaSPCN", "RemoteRef": "HEAD", "RemoteSha": "e98d94437a388865ba9c39f6f2fa4d38b4c95d02", "_user": "hanjunwei-lab", "_type": "src", "_file": "DRviaSPCN_0.1.5.tar.gz", "_fileid": "https://r2.ropensci.org/6ccdc0bb4ca3b81a5ba104516a6aea4ef9d979f89f347ba4a0b4df165949c694", "_filesize": 2859644, "_sha256": "6ccdc0bb4ca3b81a5ba104516a6aea4ef9d979f89f347ba4a0b4df165949c694", "_expires": "2026-12-26T12:09:58.000Z", "_created": "2026-09-17T11:44:26.000Z", "_published": "2026-09-17T12:10:00.271Z", "_jobs": [ { "job": 105188958184, "time": 387, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "10496400087" }, { "job": 105188958146, "time": 416, "config": "linux-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "10495068476" }, { "job": 105188958211, "time": 294, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "10496552427" }, { "job": 105188958222, "time": 253, "config": "macos-release-arm64", "r": "4.6.1", "check": "OK", "artifact": "10496097904" }, { "job": 105187181411, "time": 367, "config": "source", "r": "4.6.1", "check": "OK", "artifact": "10495004067" }, { "job": 105188958163, "time": 185, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "10494629832" }, { "job": 105188958299, "time": 354, "config": "windows-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "10495865251" }, { "job": 105188958302, "time": 359, "config": "windows-oldrel-x86_64", "r": "4.5.3", "check": "OK", "artifact": "10496175001" }, { "job": 105188958232, "time": 335, "config": "windows-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "10495817861" } ], "_host": "GitHub-Actions", "_buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/35216792004", "_status": "success", "_upstream": "https://github.com/cran/DRviaSPCN", "_commit": { "id": "e98d94437a388865ba9c39f6f2fa4d38b4c95d02", "author": "Junwei Han ", "committer": "cran-robot ", "message": "version 0.1.5\n", "time": 1736421606 }, "_maintainer": { "name": "Junwei Han", "email": "hanjunwei1981@163.com", "login": "hanjunwei-lab", "description": "Junwei Han is a professor in Harbin Medical University. His research is in the areas of bioinformatics and computational systems biology.", "uuid": 60877533 }, "_distro": "resolute", "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 3.6", "role": "Depends" }, { "package": "GSVA", "role": "Imports" }, { "package": "clusterProfiler", "role": "Imports" }, { "package": "graphics", "role": "Imports" }, { "package": "igraph", "role": "Imports" }, { "package": "pheatmap", "role": "Imports" }, { "package": "stats", "role": "Imports" }, { "package": "rmarkdown", "role": "Suggests" }, { "package": "knitr", "role": "Suggests" }, { "package": "DT", "role": "Suggests" } ], "_owner": "cran", "_selfowned": true, "_usedby": 0, "_updates": [], "_tags": [], "_stars": 0, "_contributors": [ { "user": "hanjunwei-lab", "count": 6, "uuid": 60877533 } ], "_userbio": { "uuid": 60877533, "type": "user", "name": "Junwei Han", "followers": 25, "description": "Junwei Han is a professor in Harbin Medical University. His research is in the areas of bioinformatics and computational systems biology." }, "_downloads": { "count": 275, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/DRviaSPCN" }, "_searchresults": 0, "_rbuild": "4.6.1", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/DRviaSPCN.html", "extra/manual.pdf" ], "_realowner": "hanjunwei-lab", "_cranurl": false, "_releases": [ { "version": "0.1.0", "date": "2021-12-09" }, { "version": "0.1.1", "date": "2022-02-28" }, { "version": "0.1.2", "date": "2022-03-03" }, { "version": "0.1.3", "date": "2023-09-25" }, { "version": "0.1.4", "date": "2024-01-13" }, { "version": "0.1.5", "date": "2025-01-09" } ], "_exports": [ "CalCentralityScore", "Disease2SPheatmap", "Drug2SPheatmap", "getDEscore", "GetExample", "Optimaldrugs", "PackageLoaded", "plotSPW" ], "_datasets": [ { "name": "envData", "title": "An environment variable which includes some example data", "object": "envData", "class": [ "environment" ], "fields": [], "table": false, "tojson": false } ], "_help": [ { "page": "CalCentralityScore", "title": "Calculating eigenvector centrality of subpathways", "topics": [ "CalCentralityScore" ] }, { "page": "Disease2SPheatmap", "title": "Plot a heat map of the subpathways activity regulated by disease", "topics": [ "Disease2SPheatmap" ] }, { "page": "Drug2SPheatmap", "title": "Plot a heat map of the subpathways activity regulated by drugs", "topics": [ "Drug2SPheatmap" ] }, { "page": "envData", "title": "An environment variable which includes some example data", "topics": [ "envData" ] }, { "page": "getDEscore", "title": "Calculating Log2 Fold Change of genes", "topics": [ "getDEscore" ] }, { "page": "GetExample", "title": "Get example data", "topics": [ "GetExample" ] }, { "page": "Optimaldrugs", "title": "Identifying the optimal drugs", "topics": [ "Optimaldrugs" ] }, { "page": "PackageLoaded", "title": "PackageLoaded", "topics": [ "PackageLoaded" ] }, { "page": "plotSPW", "title": "Plot subpathway network graph", "topics": [ "plotSPW" ] } ], "_rundeps": [ "abind", "aisdk", "annotate", "AnnotationDbi", "ape", "aplot", "askpass", "assorthead", "base64enc", "beachmat", "BH", "Biobase", "BiocBaseUtils", "BiocFileCache", "BiocGenerics", "biocmake", "BiocParallel", "BiocSingular", "Biostrings", "bit", "bit64", "blob", "bslib", "cachem", "callr", "cli", "cluster", "clusterProfiler", "codetools", "cpp11", "crayon", "curl", "DBI", "dbplyr", "DelayedArray", "DelayedMatrixStats", "digest", "dir.expiry", "DOSE", "dplyr", "enrichit", "enrichplot", "evaluate", "farver", "fastmap", "filelock", "fontawesome", "fontBitstreamVera", "fontLiberation", "fontquiver", "formatR", "fs", "futile.logger", "futile.options", "gdtools", "generics", "GenomicRanges", "ggforce", "ggfun", "ggiraph", "ggnewscale", "ggplot2", "ggplotify", "ggrepel", "ggtangle", "ggtree", "glue", "GO.db", "GOSemSim", "graph", "gridGraphics", "GSEABase", "gson", "GSVA", "gtable", "h5mread", "HDF5Array", "highr", "htmltools", "htmlwidgets", "httr", "httr2", "igraph", "IRanges", "irlba", "isoband", "jquerylib", "jsonlite", "KEGGREST", "knitr", "labeling", "lambda.r", "lattice", "lazyeval", "lifecycle", "magick", "magrittr", "MASS", "Matrix", "MatrixGenerics", "matrixStats", "memoise", "memuse", "mime", "nlme", "openssl", "otel", "patchwork", "pheatmap", "pillar", "pkgconfig", "plyr", "png", "polyclip", "processx", "ps", "purrr", "qvalue", "R6", "rappdirs", "RColorBrewer", "Rcpp", "RcppEigen", "reshape2", "rhdf5", "rhdf5filters", "Rhdf5lib", "rjson", "rlang", "rmarkdown", "RSQLite", "rsvd", "S4Arrays", "S4Vectors", "S7", "sass", "ScaledMatrix", "scales", "scatterpie", "Seqinfo", "SingleCellExperiment", "snow", "SparseArray", "sparseMatrixStats", "SpatialExperiment", "stringi", "stringr", "SummarizedExperiment", "sys", "systemfonts", "tibble", "tidydr", "tidyr", "tidyselect", "tidytree", "tinytex", "treeio", "tweenr", "utf8", "vctrs", "viridisLite", "withr", "xfun", "XML", "xtable", "XVector", "yaml", "yulab.utils" ], "_vignettes": [ { "source": "DRviaSPCN.Rmd", "filename": "DRviaSPCN.html", "title": "DRviaSPCN User Guide", "author": "Jiashuo Wu, Junwei Han", "engine": "knitr::rmarkdown", "headings": [ " Introduce ", "Example 1 : Calculating the centrality scores of subpathways. ", " Example 2 : Calculating the drug-disease reverse association score and corresponding pvalue of drugs. ", " Visualize 1: Plot a subpathway network structure graph. ", " Visualize 2: Plot a heatmap of the subpathways that are regulated by disease.", "", " Visualize 3: Plot heatmaps of the subpathways that are regulated by drugs." ], "created": "2021-12-09 08:00:14", "modified": "2025-01-09 11:20:06", "commits": 5 } ], "_score": 2, "_indexed": true, "_nocasepkg": "drviaspcn", "_universes": [ "hanjunwei-lab" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "0.1.5", "date": "2026-09-17T11:48:26.000Z", "distro": "resolute", "commit": "e98d94437a388865ba9c39f6f2fa4d38b4c95d02", "fileid": "https://r2.ropensci.org/5969c31829960ee348c48cd929b63c43d66e032006b0b38cc8670cbf827c0ab2", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/35216792004" }, { "r": "4.6.1", "os": "linux", "version": "0.1.5", "date": "2026-09-17T11:48:33.000Z", "distro": "resolute", "commit": "e98d94437a388865ba9c39f6f2fa4d38b4c95d02", "fileid": "https://r2.ropensci.org/e7b99a797f56ec6be17daa2454c2871bc95fce4a44e44d66848a8b389ff900df", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/35216792004" }, { "r": "4.5.3", "os": "mac", "version": "0.1.5", "date": "2026-09-17T12:06:19.000Z", "commit": "e98d94437a388865ba9c39f6f2fa4d38b4c95d02", "fileid": "https://r2.ropensci.org/de0ccc27773dfc07940375f7af9ddb558770726b185c72ce06f6c5d7b8a54815", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/35216792004" }, { "r": "4.6.1", "os": "mac", "version": "0.1.5", "date": "2026-09-17T12:05:21.000Z", "commit": "e98d94437a388865ba9c39f6f2fa4d38b4c95d02", "fileid": "https://r2.ropensci.org/fe2b2b1558cab931844858a88e4f4c99ea1c479e302c027529f3a35204cb2679", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/35216792004" }, { "r": "4.6.0", "os": "wasm", "version": "0.1.5", "date": "2026-09-17T11:48:25.000Z", "commit": "e98d94437a388865ba9c39f6f2fa4d38b4c95d02", "fileid": "https://r2.ropensci.org/f3f183ca5a1fe809c417080491087f1935602a9c11dfbbb9bcf53232e0975b6b", "status": "success", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/35216792004" }, { "r": "4.7.0", "os": "win", "version": "0.1.5", "date": "2026-09-17T11:47:17.000Z", "commit": "e98d94437a388865ba9c39f6f2fa4d38b4c95d02", "fileid": "https://r2.ropensci.org/d8e29a6e72c3e5d5fd90cfdf64b4d5a533bba8d07f37a53c8fecb3a49f7444f0", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/35216792004" }, { "r": "4.5.3", "os": "win", "version": "0.1.5", "date": "2026-09-17T11:47:30.000Z", "commit": "e98d94437a388865ba9c39f6f2fa4d38b4c95d02", "fileid": "https://r2.ropensci.org/79e4f83d722887a4d078b8fdfa6a1cef50cc2ae554d8290c7bf18a84b9994b32", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/35216792004" }, { "r": "4.6.1", "os": "win", "version": "0.1.5", "date": "2026-09-17T11:47:12.000Z", "commit": "e98d94437a388865ba9c39f6f2fa4d38b4c95d02", "fileid": "https://r2.ropensci.org/ebdd79e1c1f7d32653495f8fb9d0aea3bbf1570a63105e6caa32dd884854eb54", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/35216792004" } ] }