{
  "_id": "6a212ac3cd65a98ecbd22e4a",
  "Package": "DrugSim2DR",
  "Type": "Package",
  "Title": "Predict Drug Functional Similarity to Drug Repurposing",
  "Version": "0.1.1",
  "Maintainer": "Junwei Han <hanjunwei1981@163.com>",
  "Authors@R": "c(person(given = \"Junwei\", family = \"Han\", email = \"hanjunwei1981@163.com\", role  = c(\"aut\", \"cre\", \"cph\")),\nperson(given = \"Ji\", family = \"Li\", role  = \"aut\"),\nperson(given = \"Jiashuo\", family = \"Wu\", role  = \"aut\"))",
  "Description": "A systematic biology tool was developed to repurpose drugs\nvia a drug-drug functional similarity network. 'DrugSim2DR'\nfirst predict drug-drug functional similarity in the context of\nspecific disease, and then using the similarity constructed a\nweighted drug similarity network. Finally, it used a network\npropagation algorithm on the network to identify drugs with\nsignificant target abnormalities as candidate drugs.",
  "License": "GPL (>= 2)",
  "Encoding": "UTF-8",
  "LazyData": "true",
  "RoxygenNote": "7.2.1",
  "VignetteBuilder": "knitr",
  "Config/pak/sysreqs": "cmake libglpk-dev make libicu-dev libpng-dev\nlibrsvg2-dev libuv1-dev libxml2-dev libssl-dev",
  "Repository": "https://hanjunwei-lab.r-universe.dev",
  "Date/Publication": "2025-06-09 11:22:17 UTC",
  "RemoteUrl": "https://github.com/hanjunwei-lab/drugsim2dr",
  "RemoteRef": "HEAD",
  "RemoteSha": "697888f5bb7962f07f294c4f4452354e4dc5713c",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-06-04 07:31:38 UTC",
    "User": "root"
  },
  "Author": "Junwei Han [aut, cre, cph],\nJi Li [aut],\nJiashuo Wu [aut]",
  "MD5sum": "b36a1bfa0aeee8b5b08d83021178b50d",
  "_user": "hanjunwei-lab",
  "_type": "src",
  "_file": "DrugSim2DR_0.1.1.tar.gz",
  "_fileid": "f17c2deb8ee2edc411cd12dcdad2f2b38d3e6abc3fdb38768382c3f2f6f9d001",
  "_filesize": 1641308,
  "_sha256": "f17c2deb8ee2edc411cd12dcdad2f2b38d3e6abc3fdb38768382c3f2f6f9d001",
  "_created": "2026-06-04T07:31:38.000Z",
  "_published": "2026-06-04T07:35:31.351Z",
  "_distro": "noble",
  "_jobs": [
    {
      "job": 79471006795,
      "time": 187,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "WARNING",
      "artifact": "7405608292"
    },
    {
      "job": 79471006790,
      "time": 181,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "WARNING",
      "artifact": "7405607067"
    },
    {
      "job": 79471006827,
      "time": 117,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "WARNING",
      "artifact": "7405595753"
    },
    {
      "job": 79471006771,
      "time": 168,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "WARNING",
      "artifact": "7405606469"
    },
    {
      "job": 79470207604,
      "time": 332,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7405551663"
    },
    {
      "job": 79471006726,
      "time": 149,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7405596990"
    },
    {
      "job": 79471006749,
      "time": 129,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "WARNING",
      "artifact": "7405591238"
    },
    {
      "job": 79471006773,
      "time": 125,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "WARNING",
      "artifact": "7405589881"
    },
    {
      "job": 79471006791,
      "time": 136,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "WARNING",
      "artifact": "7405593009"
    }
  ],
  "_buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/26937349640",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/hanjunwei-lab/drugsim2dr",
  "_commit": {
    "id": "697888f5bb7962f07f294c4f4452354e4dc5713c",
    "author": "Junwei Han <hanjunwei1981@163.com>",
    "committer": "GitHub <noreply@github.com>",
    "message": "Update README.md",
    "time": 1749468137
  },
  "_maintainer": {
    "name": "Junwei Han",
    "email": "hanjunwei1981@163.com",
    "login": "hanjunwei-lab",
    "description": "Junwei Han is a professor in Harbin Medical University. His research is in the areas of bioinformatics and computational systems biology.",
    "uuid": 60877533
  },
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 3.6",
      "role": "Depends"
    },
    {
      "package": "igraph",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "pheatmap",
      "role": "Imports"
    },
    {
      "package": "ChemmineR",
      "role": "Imports"
    },
    {
      "package": "rvest",
      "role": "Imports"
    },
    {
      "package": "base",
      "role": "Imports"
    },
    {
      "package": "sp",
      "role": "Imports"
    },
    {
      "package": "tidyr",
      "role": "Imports"
    },
    {
      "package": "reshape2",
      "role": "Imports"
    },
    {
      "package": "fastmatch",
      "role": "Imports"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    }
  ],
  "_owner": "hanjunwei-lab",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2025-24",
      "n": 1
    }
  ],
  "_tags": [],
  "_stars": 2,
  "_contributors": [
    {
      "user": "hanjunwei-lab",
      "count": 5,
      "uuid": 60877533
    }
  ],
  "_userbio": {
    "uuid": 60877533,
    "type": "user",
    "name": "Junwei Han",
    "description": "Junwei Han is a professor in Harbin Medical University. His research is in the areas of bioinformatics and computational systems biology."
  },
  "_downloads": {
    "count": 162,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/DrugSim2DR"
  },
  "_devurl": "https://github.com/hanjunwei-lab/drugsim2dr",
  "_searchresults": 2,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/DrugSim2DR.html",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/hanjunwei-lab/drugsim2dr",
  "_realowner": "hanjunwei-lab",
  "_cranurl": true,
  "_releases": [
    {
      "version": "0.1.0",
      "date": "2022-11-09"
    },
    {
      "version": "0.1.1",
      "date": "2023-08-10"
    },
    {
      "version": "0.1.2",
      "date": "2025-10-28"
    }
  ],
  "_exports": [
    "CalDEscore",
    "DrugReposition",
    "DrugSimscore",
    "Gettest",
    "plotDruglink",
    "plotDrugstructure",
    "plotTargetheatmap"
  ],
  "_datasets": [
    {
      "name": "myenv",
      "title": "An environment variable which includes some example data",
      "object": "myenv",
      "class": [
        "environment"
      ],
      "fields": [],
      "table": false,
      "tojson": false
    }
  ],
  "_help": [
    {
      "page": "CalDEscore",
      "title": "CalDEscore",
      "topics": [
        "CalDEscore"
      ]
    },
    {
      "page": "datasummary",
      "title": "datasummary: Custom Data Summaries",
      "topics": [
        "DrugSim2DR-package",
        "DrugSim2DR"
      ]
    },
    {
      "page": "DrugReposition",
      "title": "DrugReposition",
      "topics": [
        "DrugReposition"
      ]
    },
    {
      "page": "DrugSimscore",
      "title": "DrugSimscore",
      "topics": [
        "DrugSimscore"
      ]
    },
    {
      "page": "Gettest",
      "title": "Gettest",
      "topics": [
        "Gettest"
      ]
    },
    {
      "page": "myenv",
      "title": "An environment variable which includes some example data",
      "topics": [
        "myenv"
      ]
    },
    {
      "page": "plotDruglink",
      "title": "plotDruglink",
      "topics": [
        "plotDruglink"
      ]
    },
    {
      "page": "plotDrugstructure",
      "title": "plotDrugstructure",
      "topics": [
        "plotDrugstructure"
      ]
    },
    {
      "page": "plotTargetheatmap",
      "title": "plotTargetheatmap",
      "topics": [
        "plotTargetheatmap"
      ]
    }
  ],
  "_readme": "https://github.com/hanjunwei-lab/drugsim2dr/raw/HEAD/README.md",
  "_rundeps": [
    "askpass",
    "base64enc",
    "BH",
    "BiocGenerics",
    "bitops",
    "bslib",
    "cachem",
    "ChemmineR",
    "cli",
    "cpp11",
    "crosstalk",
    "curl",
    "DBI",
    "digest",
    "dplyr",
    "DT",
    "evaluate",
    "farver",
    "fastmap",
    "fastmatch",
    "fontawesome",
    "fs",
    "generics",
    "ggplot2",
    "glue",
    "gridExtra",
    "gtable",
    "highr",
    "htmltools",
    "htmlwidgets",
    "httr",
    "igraph",
    "isoband",
    "jquerylib",
    "jsonlite",
    "knitr",
    "labeling",
    "later",
    "lattice",
    "lazyeval",
    "lifecycle",
    "magrittr",
    "Matrix",
    "memoise",
    "mime",
    "openssl",
    "otel",
    "pheatmap",
    "pillar",
    "pkgconfig",
    "plyr",
    "png",
    "promises",
    "purrr",
    "R6",
    "rappdirs",
    "RColorBrewer",
    "Rcpp",
    "RCurl",
    "reshape2",
    "rjson",
    "rlang",
    "rmarkdown",
    "rsvg",
    "rvest",
    "S7",
    "sass",
    "scales",
    "selectr",
    "sp",
    "stringi",
    "stringr",
    "sys",
    "tibble",
    "tidyr",
    "tidyselect",
    "tinytex",
    "utf8",
    "vctrs",
    "viridisLite",
    "withr",
    "xfun",
    "xml2",
    "yaml"
  ],
  "_vignettes": [
    {
      "source": "DrugSim2DR.Rmd",
      "filename": "DrugSim2DR.html",
      "title": "DrugSim2DR User Guide",
      "author": "Ji Li, Jiashuo Wu, JunweiHan",
      "engine": "knitr::rmarkdown",
      "headings": [
        "<font face=\"微软雅黑\"> Introduce </font>",
        "<font face=\"微软雅黑\">Example 1 : Calculate the DEscore. </font>",
        "<font face=\"微软雅黑\"> Example 2 : Calculate drug-drug functional similarity. </font>",
        "<font face=\"微软雅黑\"> Example 3 : Identify candidate drugs by random-walk algorithm. </font>",
        "<font face=\"微软雅黑\"> Visualize 1: Plot the chemical structure of a compound. </font>",
        "<font face=\"微软雅黑\"> Visualize 2: Plot the heatmap of drug targets expression.</font>",
        "",
        "<font face=\"微软雅黑\"> Visualize 3: Plot a drug/GO bipartite network.</font>"
      ],
      "created": "2023-08-02 10:45:39",
      "modified": "2023-08-02 10:45:39",
      "commits": 1
    }
  ],
  "_score": 4,
  "_indexed": true,
  "_nocasepkg": "drugsim2dr",
  "_universes": [
    "hanjunwei-lab"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "0.1.1",
      "date": "2026-06-04T07:34:23.000Z",
      "distro": "noble",
      "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c",
      "fileid": "f54e6b1c3e6c4ba342720bc798f47e37a4af547f4d2fcb056055e6505e28fd0d",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/26937349640"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "0.1.1",
      "date": "2026-06-04T07:34:24.000Z",
      "distro": "noble",
      "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c",
      "fileid": "bbcdf4189779f1688408836647147ea594046af6b7f627b0a13235b56898f776",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/26937349640"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "0.1.1",
      "date": "2026-06-04T07:33:51.000Z",
      "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c",
      "fileid": "6346ac00a50b8ff36fa581e18629738b37f74fb3aa7e7bf0640e3e860929c816",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/26937349640"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "0.1.1",
      "date": "2026-06-04T07:34:14.000Z",
      "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c",
      "fileid": "f6393bee1a0b5207839db2f2fb42364c670e93272153a8c94ef516b4a95824d8",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/26937349640"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "0.1.1",
      "date": "2026-06-04T07:34:32.000Z",
      "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c",
      "fileid": "d8a920bc677bff266e5abbc7b1f1dea7a14fdfbbf8e9149f5065719b69d93b8d",
      "status": "success",
      "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/26937349640"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "0.1.1",
      "date": "2026-06-04T07:33:22.000Z",
      "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c",
      "fileid": "a9a3f4fde30a9b297c3f48b45c12f8bc509065bc68a3deabc460dd115f3cebaf",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/26937349640"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "0.1.1",
      "date": "2026-06-04T07:33:14.000Z",
      "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c",
      "fileid": "865a4a5d7a149b3289295bdd2382baa4b0b62b80728364e791d33f9b6195d961",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/26937349640"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "0.1.1",
      "date": "2026-06-04T07:33:26.000Z",
      "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c",
      "fileid": "41b921810e1c4c930885095968a729a764fe43235ac0ea0f20fee3be5121f79d",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/26937349640"
    }
  ]
}