{ "_id": "6a48a749e06c18f0a6545610", "Package": "DrugSim2DR", "Type": "Package", "Title": "Predict Drug Functional Similarity to Drug Repurposing", "Version": "0.1.1", "Maintainer": "Junwei Han ", "Authors@R": "c(person(given = \"Junwei\", family = \"Han\", email = \"hanjunwei1981@163.com\", role = c(\"aut\", \"cre\", \"cph\")),\nperson(given = \"Ji\", family = \"Li\", role = \"aut\"),\nperson(given = \"Jiashuo\", family = \"Wu\", role = \"aut\"))", "Description": "A systematic biology tool was developed to repurpose drugs\nvia a drug-drug functional similarity network. 'DrugSim2DR'\nfirst predict drug-drug functional similarity in the context of\nspecific disease, and then using the similarity constructed a\nweighted drug similarity network. Finally, it used a network\npropagation algorithm on the network to identify drugs with\nsignificant target abnormalities as candidate drugs.", "License": "GPL (>= 2)", "Encoding": "UTF-8", "LazyData": "true", "RoxygenNote": "7.2.1", "VignetteBuilder": "knitr", "Config/pak/sysreqs": "cmake libglpk-dev make libicu-dev libpng-dev\nlibrsvg2-dev libuv1-dev libxml2-dev libssl-dev", "Repository": "https://hanjunwei-lab.r-universe.dev", "Date/Publication": "2025-06-09 11:22:17 UTC", "RemoteUrl": "https://github.com/hanjunwei-lab/drugsim2dr", "RemoteRef": "HEAD", "RemoteSha": "697888f5bb7962f07f294c4f4452354e4dc5713c", "NeedsCompilation": "no", "Packaged": { "Date": "2026-07-04 05:56:51 UTC", "User": "root" }, "Author": "Junwei Han [aut, cre, cph],\nJi Li [aut],\nJiashuo Wu [aut]", "_user": "hanjunwei-lab", "_type": "src", "_file": "DrugSim2DR_0.1.1.tar.gz", "_fileid": "https://r2.ropensci.org/d70578abf4db7757972e381eb8c2ceef25eba4a33c09df6717922f63e7b7e952", "_filesize": 1641217, "_sha256": "d70578abf4db7757972e381eb8c2ceef25eba4a33c09df6717922f63e7b7e952", "_expires": "2026-10-12T06:25:11.000Z", "_created": "2026-07-04T05:56:51.000Z", "_published": "2026-07-04T06:25:13.173Z", "_jobs": [ { "job": 85108183529, "time": 182, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "WARNING", "artifact": "8078908719" }, { "job": 85108183537, "time": 190, "config": "linux-release-x86_64", "r": "4.6.1", "check": "WARNING", "artifact": "8078909481" }, { "job": 85108183541, "time": 105, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "WARNING", "artifact": "8079106810" }, { "job": 85108183543, "time": 111, "config": "macos-release-arm64", "r": "4.6.1", "check": "WARNING", "artifact": "8079093059" }, { "job": 85107928276, "time": 211, "config": "source", "r": "4.6.1", "check": "OK", "artifact": "8078887473" }, { "job": 85108183528, "time": 176, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "8078908033" }, { "job": 85108183534, "time": 134, "config": "windows-devel", "r": "4.7.0", "check": "WARNING", "artifact": "8078903187" }, { "job": 85108183538, "time": 123, "config": "windows-oldrel", "r": "4.5.3", "check": "WARNING", "artifact": "8078902073" }, { "job": 85108183532, "time": 144, "config": "windows-release", "r": "4.6.1", "check": "WARNING", "artifact": "8078904651" } ], "_host": "GitHub-Actions", "_buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/28696870133", "_status": "success", "_upstream": "https://github.com/hanjunwei-lab/drugsim2dr", "_commit": { "id": "697888f5bb7962f07f294c4f4452354e4dc5713c", "author": "Junwei Han ", "committer": "GitHub ", "message": "Update README.md", "time": 1749468137 }, "_maintainer": { "name": "Junwei Han", "email": "hanjunwei1981@163.com", "login": "hanjunwei-lab", "description": "Junwei Han is a professor in Harbin Medical University. His research is in the areas of bioinformatics and computational systems biology.", "uuid": 60877533 }, "_distro": "resolute", "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 3.6", "role": "Depends" }, { "package": "igraph", "role": "Imports" }, { "package": "stats", "role": "Imports" }, { "package": "pheatmap", "role": "Imports" }, { "package": "ChemmineR", "role": "Imports" }, { "package": "rvest", "role": "Imports" }, { "package": "base", "role": "Imports" }, { "package": "sp", "role": "Imports" }, { "package": "tidyr", "role": "Imports" }, { "package": "reshape2", "role": "Imports" }, { "package": "fastmatch", "role": "Imports" }, { "package": "knitr", "role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" } ], "_owner": "hanjunwei-lab", "_selfowned": true, "_usedby": 0, "_updates": [], "_tags": [], "_stars": 2, "_contributors": [ { "user": "hanjunwei-lab", "count": 5, "uuid": 60877533 } ], "_userbio": { "uuid": 60877533, "type": "user", "name": "Junwei Han", "followers": 25, "description": "Junwei Han is a professor in Harbin Medical University. His research is in the areas of bioinformatics and computational systems biology." }, "_downloads": { "count": 297, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/DrugSim2DR" }, "_devurl": "https://github.com/hanjunwei-lab/drugsim2dr", "_searchresults": 2, "_rbuild": "4.6.1", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/DrugSim2DR.html", "extra/readme.html", "extra/readme.md", "LICENSE", "manual.pdf" ], "_homeurl": "https://github.com/hanjunwei-lab/drugsim2dr", "_realowner": "hanjunwei-lab", "_cranurl": true, "_releases": [ { "version": "0.1.0", "date": "2022-11-09" }, { "version": "0.1.1", "date": "2023-08-10" }, { "version": "0.1.2", "date": "2025-10-28" } ], "_exports": [ "CalDEscore", "DrugReposition", "DrugSimscore", "Gettest", "plotDruglink", "plotDrugstructure", "plotTargetheatmap" ], "_datasets": [ { "name": "myenv", "title": "An environment variable which includes some example data", "object": "myenv", "class": [ "environment" ], "fields": [], "table": false, "tojson": false } ], "_help": [ { "page": "CalDEscore", "title": "CalDEscore", "topics": [ "CalDEscore" ] }, { "page": "datasummary", "title": "datasummary: Custom Data Summaries", "topics": [ "DrugSim2DR-package", "DrugSim2DR" ] }, { "page": "DrugReposition", "title": "DrugReposition", "topics": [ "DrugReposition" ] }, { "page": "DrugSimscore", "title": "DrugSimscore", "topics": [ "DrugSimscore" ] }, { "page": "Gettest", "title": "Gettest", "topics": [ "Gettest" ] }, { "page": "myenv", "title": "An environment variable which includes some example data", "topics": [ "myenv" ] }, { "page": "plotDruglink", "title": "plotDruglink", "topics": [ "plotDruglink" ] }, { "page": "plotDrugstructure", "title": "plotDrugstructure", "topics": [ "plotDrugstructure" ] }, { "page": "plotTargetheatmap", "title": "plotTargetheatmap", "topics": [ "plotTargetheatmap" ] } ], "_readme": "https://github.com/hanjunwei-lab/drugsim2dr/raw/HEAD/README.md", "_rundeps": [ "askpass", "base64enc", "BH", "BiocGenerics", "bitops", "bslib", "cachem", "ChemmineR", "cli", "cpp11", "crosstalk", "curl", "DBI", "digest", "dplyr", "DT", "evaluate", "farver", "fastmap", "fastmatch", "fontawesome", "fs", "generics", "ggplot2", "glue", "gridExtra", "gtable", "highr", "htmltools", "htmlwidgets", "httr", "igraph", "isoband", "jquerylib", "jsonlite", "knitr", "labeling", "later", "lattice", "lazyeval", "lifecycle", "magrittr", "Matrix", "memoise", "mime", "openssl", "otel", "pheatmap", "pillar", "pkgconfig", "plyr", "png", "promises", "purrr", "R6", "rappdirs", "RColorBrewer", "Rcpp", "RCurl", "reshape2", "rjson", "rlang", "rmarkdown", "rsvg", "rvest", "S7", "sass", "scales", "selectr", "sp", "stringi", "stringr", "sys", "tibble", "tidyr", "tidyselect", "tinytex", "utf8", "vctrs", "viridisLite", "withr", "xfun", "xml2", "yaml" ], "_vignettes": [ { "source": "DrugSim2DR.Rmd", "filename": "DrugSim2DR.html", "title": "DrugSim2DR User Guide", "author": "Ji Li, Jiashuo Wu, JunweiHan", "engine": "knitr::rmarkdown", "headings": [ " Introduce ", "Example 1 : Calculate the DEscore. ", " Example 2 : Calculate drug-drug functional similarity. ", " Example 3 : Identify candidate drugs by random-walk algorithm. ", " Visualize 1: Plot the chemical structure of a compound. ", " Visualize 2: Plot the heatmap of drug targets expression.", "", " Visualize 3: Plot a drug/GO bipartite network." ], "created": "2023-08-02 10:45:39", "modified": "2023-08-02 10:45:39", "commits": 1 } ], "_score": 4, "_indexed": true, "_nocasepkg": "drugsim2dr", "_universes": [ "hanjunwei-lab" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "0.1.1", "date": "2026-07-04T05:59:27.000Z", "distro": "resolute", "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c", "fileid": "https://r2.ropensci.org/d8b0e5b80398c639bee7cdb8a8402b40b63d837efaf2761bf32d314ff9aa7b03", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/28696870133" }, { "r": "4.6.1", "os": "linux", "version": "0.1.1", "date": "2026-07-04T05:59:36.000Z", "distro": "resolute", "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c", "fileid": "https://r2.ropensci.org/f296c91ff50b14e867dbd7ede29e61bf7f456aa32caa4c7cd81f275d6a875c47", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/28696870133" }, { "r": "4.5.3", "os": "mac", "version": "0.1.1", "date": "2026-07-04T06:24:14.000Z", "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c", "fileid": "https://r2.ropensci.org/feeb0841e2824e2c96f2a613eba3aefd8c5bcab7cf9031ed5552196148c29388", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/28696870133" }, { "r": "4.6.1", "os": "mac", "version": "0.1.1", "date": "2026-07-04T06:22:25.000Z", "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c", "fileid": "https://r2.ropensci.org/c290e90cd80c1aadbb2252d561bdfb60b4dab84d53e0742c1f042a4811fc7629", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/28696870133" }, { "r": "4.6.0", "os": "wasm", "version": "0.1.1", "date": "2026-07-04T06:00:03.000Z", "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c", "fileid": "https://r2.ropensci.org/d4b57d815928bd76042a17fc87fc0a10e03188530249849423bcaeb3d57f6fe5", "status": "success", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/28696870133" }, { "r": "4.7.0", "os": "win", "version": "0.1.1", "date": "2026-07-04T05:58:28.000Z", "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c", "fileid": "https://r2.ropensci.org/a6f21cac1fe9745ab54158d7b27dcb209b1a803c72b1734c579f555d58c1f14a", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/28696870133" }, { "r": "4.5.3", "os": "win", "version": "0.1.1", "date": "2026-07-04T05:58:22.000Z", "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c", "fileid": "https://r2.ropensci.org/9ef660b3eead5caaff1017b5b81cafba894478f50270a2d4dd09604ae40e8317", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/28696870133" }, { "r": "4.6.1", "os": "win", "version": "0.1.1", "date": "2026-07-04T05:58:42.000Z", "commit": "697888f5bb7962f07f294c4f4452354e4dc5713c", "fileid": "https://r2.ropensci.org/5b0417d7f890f1b2935b3fa92706a75410e277ad0912bd6df1b5300e26c2334f", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/hanjunwei-lab/actions/runs/28696870133" } ] }