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  "Title": "Prioritization of Candidate Cancer Subtype Specific Drugs",
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  "Author": "Xudong Han, Junwei Han, Chonghui Liu",
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  "Description": "A systematic biology tool was developed to prioritize\ncancer subtype-specific drugs by integrating genetic\nperturbation, drug action, biological pathway, and cancer\nsubtype. The capabilities of this tool include inferring\npatient-specific subpathway activity profiles in the context of\ngene expression profiles with subtype labels, calculating\ndifferentially expressed subpathways based on cultured human\ncells treated with drugs in the 'cMap' (connectivity map)\ndatabase, prioritizing cancer subtype specific drugs according\nto drug-disease reverse association score based on subpathway,\nand visualization of results (Castelo (2013)\n<doi:10.1186/1471-2105-14-7>; Han et al (2019)\n<doi:10.1093/bioinformatics/btz894>; Lamb and Justin (2006)\n<doi:10.1126/science.1132939>). Please cite using\n<doi:10.1093/bioinformatics/btab011>.",
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      "title": "SubtypeDrug: a software package for prioritization of candidate cancer subtype-specific drugs",
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        "Calculating drug-disease reverse association score.",
        "Identifying cancer subtype-specific drugs",
        "Calculating the cancer subtype-specific drug score",
        "Estimating statistically significance level of sutype-specific drug score",
        "Visualization",
        "Plot a heat map of normalized drug-disease reverse association scores for cancer samples",
        "Plot heat map of patient-specific subpathway activity profiles of drug-regulated subpathway",
        "Plot a global graph of the drug",
        "Polt a subpathway network graph",
        "Visualize the chemical structure of the drug",
        "References"
      ],
      "created": "2021-01-22 09:58:26",
      "modified": "2021-01-22 09:58:26",
      "commits": 1
    }
  ],
  "_score": 4,
  "_indexed": true,
  "_nocasepkg": "subtypedrug",
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