{ "_id": "6ac4c499f511ae58c09a111b", "Package": "ssMutPA", "Type": "Package", "Title": "Single-Sample Mutation-Based Pathway Analysis", "Version": "0.1.1", "Authors@R": "c(person(given = \"Junwei\", family = \"Han\", email = \"hanjunwei1981@163.com\", role = c(\"aut\", \"cre\", \"cph\")),\nperson(given = \"Yalan\", family = \"He\", role = \"aut\"),\nperson(given = \"Qian\", family = \"Wang\", role = \"aut\"))", "Description": "A systematic bioinformatics tool to perform single-sample\nmutation-based pathway analysis by integrating somatic mutation\ndata with the Protein-Protein Interaction (PPI) network. In\nthis method, we use local and global weighted strategies to\nevaluate the effects of network genes from mutations according\nto the network topology and then calculate the mutation-based\npathway enrichment score (ssMutPES) to reflect the accumulated\neffect of mutations of each pathway. 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