Package: CITMIC 0.1.1

CITMIC: Estimation of Cell Infiltration Based on Cell Crosstalk

A systematic biology tool was developed to identify cell infiltration via an Individualized Cell crosstalk network. 'CITMIC' first constructed a weighted cell crosstalk network by integrating Cell-target interaction information, biological process data from the Gene Ontology (GO) database, and gene transcriptomic data in a specific sample, and then, it used a network propagation algorithm on the network to identify cell infiltration for the sample. Ultimately, cell infiltration in the patient dataset was obtained by normalizing the centrality scores of the cells.

Authors:Junwei Han [aut, cre, cph], Xilong Zhao [aut]